Application of Chitosan Microspheres as Drug Carriers : a Review
نویسندگان
چکیده
Rahul Nair*, B.Haritha Reddy C.K.Ashok Kumar, K.Jayraj Kumar. 1.Sree Vidyanikethan College of Pharmacy, A.Rangampet, Chittoor District Tirupathi, Andhra Pradesh. 2. D.R.Karigowda College of Pharmacy Hassan. Karnataka. ______________________________________________________________________________________ ABSTRACT Chitosan (CS) is a naturally occurring polymer which finds a wide array of pharmaceutical applications due to its low production costs, biodegradability, biocompatibility, nontoxic nature and mucoadhesion. As a result of its cationic character, CS is able to react with polyanions giving rise to polyelectrolyte complexes. CS has found pronounced application in multiparticulate drug delivery and it enhances the dissolution of drugs having poor solubility. CS microspheres can be prepared by chemical denaturation process, ion induced coagulation and spray drying methods. This review aims to compile the various application of CS in microspheres based drug delivery. This review also aims to include the process variables factors that affect the release of drugs from the microspheres.
منابع مشابه
Formulation and In Vitro Evaluation of Acyclovir Mucoadhesive Microspheres for Intravaginal Application
The purpose of the research was to formulate microspheres of acyclovir (ACV) using mucoadhesive polymers, sodium alginate and chitosan. Calcium chloride was used as the ionotropic gelling agent. Sodium alginate was crosslinked by calcium chloride leading to a slower release of the drug. Chitosan which is a cationic polymer interacted with sodium alginate, an anionic polymer, to form an interpol...
متن کاملChemotherapeutic potential of alginate-chitosan microspheres as anti-tubercular drug carriers.
OBJECTIVES This study was designed to develop alginate-chitosan microspheres as drug carriers to reduce dose/dosing frequency in the management of tuberculosis (TB), which otherwise demands prolonged chemotherapy. METHODS Alginate-chitosan microspheres encapsulating three frontline anti-tuberculous drugs (ATDs), rifampicin, isoniazid and pyrazinamide, were formulated. A therapeutic dose and a...
متن کاملDesign and application of chitosan microspheres as oral and nasal vaccine carriers: an updated review
Chitosan, a natural biodegradable polymer, is of great interest in biomedical research due to its excellent properties including bioavailability, nontoxicity, high charge density, and mucoadhesivity, which creates immense potential for various pharmaceutical applications. It has gelling properties when it interacts with counterions such as sulfates or polyphosphates and when it crosslinks with ...
متن کاملPreparation and Characterization of Quaternized Chitosan Coated Alginate Microspheres for Blue Dextran Delivery
In this study, 2-[(Acryloyloxy)ethyl]trimethylammonium chloride was graft polymerized onto chitosan (CS) to form quaternary ammonium CS (QAC) by using ammonium persulfate as a redox initiator. Alginate (ALG) microspheres loaded with a water-soluble macromolecular model drug, blue dextran (BD), were obtained by corporation of coaxial gas-flow method and ionic gelation process. CS and QAC were th...
متن کاملChitosan Microspheres in Novel Drug Delivery Systems
The main aim in the drug therapy of any disease is to attain the desired therapeutic concentration of the drug in plasma or at the site of action and maintain it for the entire duration of treatment. A drug on being used in conventional dosage forms leads to unavoidable fluctuations in the drug concentration leading to under medication or overmedication and increased frequency of dose administr...
متن کامل